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Inhibition of HDACs reduces arachidonic acid-induced vessel relaxation. Vascular response assays of carotid rings. Relaxations to PGE2 (A) and arachidonic acid (100 nmol/l) (B) in combination with and without diclofenac (Diclo; 10 μmol/l) and the NO donor DETA NONOate (C) in U46619 preconstricted vessels. D: Contractions to the TX receptor agonist, U46619. Carotid rings were incubated with SAHA (2 μmol/l, 14 h) or with control solvent DMSO (Ctl). *P < 0.05, n = 7–10.
