Fig. 4.
Far UV circular dichroic spectra of LXRα in the absence (filled circles) and presence of added ligand at a concentration of 0.6 μM: octanoic acid, C8:0 (open circles) (A) or octanoyl-CoA, C8:0-CoA (open circles) (D); decanoic acid, C10:0 (open circles) (B) or decanoyl-CoA, C10:0-CoA (open circles) (E); lauric acid, C12:0 (open circles) (C) or lauroyl-CoA, C12:0-CoA (open circles) (F); palmitic acid, C16:0 (open circles) (G) or palmitoyl-CoA, C16:0-CoA (open circles) (H); T-0901317 (open circles) or 25-hydroxycholesterol (25-HC) (filled triangle) (I). Each spectrum represents an average of 10 scans for a given representative spectrum from at least three replicates.