TABLE 2.
Associations of longitudinal percent changes in cholesterol variables with MRI and clinical outcomes
| Clinical/MRI Variablea | Longitudinal Percent Changes in Cholesterol Variablesb | ||
| ΔTC% | ΔLDL-C% | ΔHDL-C% | |
| PBVC | −1.09 (< 0.001) | 0.0113 (0.95) | −0.835 (0.001) |
| PGMVC | 0.0137 (0.98) | 1.21 (< 0.001) | −1.34 (0.002) |
| PLVVC | 1.30 (0.51) | −4.48 (0.001) | 6.10 (0.001) |
| New T2 lesions | 2.90 (0.027) | 0.838 (0.35) | 3.29 (0.009) |
| New/enlarging T2 lesions | 3.69 (0.038) | 1.18 (0.33) | 4.47 (0.009) |
| CEL | 5.16 (< 0.001) | 3.51 (< 0.001) | 2.39 (0.023) |
| EDSS | 0.145 (0.36) | 0.105 (0.33) | 0.0054 (0.97) |
| Cumulative relapses | 0.289 (0.059) | 0.0458 (0.674) | 0.252 (0.089) |
Slope (P values) from mixed effect models are summarized.
a
In MS decreases in normalized brain volume, decreases in gray matter volume, increases in lateral ventricle volume, increases in the number of T2 lesions, increases in contrast enhancing lesions (CEL), increases in EDSS and increases in cumulative relapses are adverse MRI/clinical outcomes.
b
Percent changes in lipid variables (ΔTC%, ΔLDL-C%, ΔHDL-C%) are positive when the lipid level is increased relative to baseline, zero when the lipid variable is unchanged relative to baseline, and negative when the lipid variable is decreased relative to baseline.