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. Author manuscript; available in PMC: 2017 Jan 31.
Published in final edited form as: Kidney Int. 2013 Oct 2;85(1):134–141. doi: 10.1038/ki.2013.357

Figure 6.

Figure 6

CDDO-Im did not confer protection against renal ischemia reperfusion injury in Nrf2−/− mice. Nrf2−/− mice were generated as previously described. Mice were administered either CDDO-Im (30 µmol/kg in 200 µl volume) or vehicle at -24 h, -3 h, and at 24 h after undergoing 30 min bilateral kidney ischemia followed by reperfusion for 72 h. (A–D) Mice receiving CDDO-Im showed no improvement in survival, renal function, renal injury score, Nrf2 target gene expression, or inflammatory cytokine profile at 72 h after kidney IRI when compared with mice receiving vehicle. Data presented are the mean fold change ± SEM from 4–8 mice per group.