Table 2.
Associations between DSS of CM patients and selected SNPs in the PIWI-piRNA pathway in the MDACC dataset.
| Genotype | No. of patients | Death (%) | Univariate analysis | Multivariate analysis* | ||
|---|---|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |||
| PIWIL4 | ||||||
| rs7933369 | ||||||
| GG | 250 | 22 (8.8) | 1.00 | 1.00 | ||
| AG | 427 | 40 (9.4) | 1.07 (0.64–1.80) | 0.797 | 1.44 (0.83–2.51) | 0.193 |
| AA | 181 | 33 (18.2) | 2.20 (1.28–3.78) | 0.004 | 3.66 (2.04–6.56) | 1.31×10−5 |
| Trend | 1.53 (1.15–2.05) | 0.004 | 1.97 (1.45–2.67) | 1.43×10−5 | ||
| PIWIL4 | ||||||
| rs508485 | ||||||
| TT | 224 | 34 (15.2) | 1.00 | 1.00 | ||
| CT | 430 | 46 (10.7) | 0.68 (0.44–1.07) | 0.092 | 0.59 (0.38–0.93) | 0.024 |
| CC | 204 | 15 (7.4) | 0.46 (0.25–0.84) | 0.012 | 0.32 (0.17–0.60) | 0.0004 |
| Trend | 0.68 (0.51–0.91) | 0.009 | 0.57 (0.42–0.77) | 0.0002 | ||
| DCP1A | ||||||
| rs11551405 | ||||||
| CC | 530 | 47 (8.9) | 1.00 | 1.00 | ||
| AC | 287 | 39 (13.6) | 1.60 (1.05–2.44) | 0.030 | 2.02 (1.30–3.15) | 1.80×10−3 |
| AA | 41 | 9 (22.0) | 2.97 (1.45–6.07) | 0.003 | 2.23 (1.03–4.81) | 0.041 |
| Trend | 1.67 (1.22–2.29) | 0.001 | 1.66 (1.21–2.27) | 1.50×10−3 | ||
SNP, single nucleotide polymorphisms; CM, cutaneous melanoma; HR, hazards ratio; DSS, disease-specific survival; HR, hazards ratio; 95%CI, 95% confidence interval;
*
Adjusted by age, sex, tumor stage, Breslow thickness, ulceration of tumor, tumor cell mitotic rate in the Cox models, in additive model.