Table 2.
Comparison of thermal pain sensitivity, conditioned pain modulation, and upper GI visceral sensitivity in women with IBS compared to HC
| HC vs IBS | IBS Subgroups | |||||||
|---|---|---|---|---|---|---|---|---|
| HC n = 31 |
IBS n = 46 |
pa | IBS-CM n = 22 |
IBS-D n = 24 |
pb | pc | p d | |
| Thermal pain sensitivity | ||||||||
| 45 °C | 3.8 (2.4) | 3.5 (2.0) | NS | 4.2 (2.1) | 2.9 (1.6) | NS | .165 | .171 |
| 46 °C | 4.2 (2.7) | 4.3 (2.3) | NS | 5.3 (2.3) | 3.3 (1.7) | .121 | NS | .005 |
| 47 °C | 5.3 (2.5) | 5.4 (2.4) | NS | 6.4 (2.3) | 4.5 (2.2) | .141 | NS | .011 |
| 48 °C | 6.3 (2.4) | 6.7 (2.2) | NS | 7.5 (2.1) | 5.9 (2.0) | .079 | NS | .011 |
| CPM efficiency score | 1.1 (1.3) | 0.9 (1.1) | NS | .8 | 1.1 (0.9) | NS | NS | .096 |
| Visceral Pain Sensitivity | ||||||||
| Pain/discomfort | 15.4 (17.5) | 26.9 (16.0) | .001 | 31.9 (16.9) | 22.3 (14.4) | .001 | .016 | .039 |
| Bloating | 20.6 (21.7) | 34.6 (20.3) | .003 | 38.9 (20.9) | 30.8 (19.0) | .003 | .039 | .187 |
| Fullness | 35.3 (19.9) | 44.6 (17.4) | .050 | 50.0 (16.7) | 39.7 (16.8) | .006 | NS | .014 |
| Nausea | 12.5 (19.1) | 22.9 (20.3) | .003 | 24.2 (20.7) | 21.7 (20.3) | .005 | .024 | NS |
Note: IBS = irritable bowel syndrome. HC = healthy controls. IBS-CM = Constipation- and Mixed-predominant irritable bowel syndrome (IBS) group. IBS-D = Diarrhea-predominant IBS group. CPM = conditioned pain modulation.
P values were determined using Mann–Whitney test.
pa= 2 group comparison of IBS vs. HC; pb = IBS-CM vs. HC; pc = IBS-D vs. HC; pd = IBS-CM vs. IBS-D. NS = non-significant (p > .20).