Table 5.
Blinded video analyses of abnormal movements in preweanling Sgcem+/pGt mice and WT littermates at P14 and P16.
| Sex, Genotypes (numbers, age) | Total scorea (mean ± SEM) | Number of genotype-phenotype matchesb | Percent correct |
|---|---|---|---|
| M, WT (n=5, P14) | 1.7 ± 1.2 | 4/5 | 80.0 |
| M, Sgcem+/pGt (n=5, P14) | 8.3 ± 3.3* | 5/5 | 100.0 |
| M, WT (n=10, P16) | 18.7 ± 4.7 | 22/30 | 73.3 |
| M, Sgcem+/pGt (n=10, P16) | 36.0 ± 5.3* | 18/30 | 60.0 |
| F, WT (n=10, P16) | 20.0 ± 8.1 | 23/30 | 76.7 |
| F, Sgcem+/pGt (n=10, P16) | 39.0 ± 10.4* | 22/30 | 73.3 |
a
Mean total scores for abnormal movements were generated by three blinded raters.
b
Genotype-phenotype matches were declared if ≥ 2/3 of the raters scored the presence of abnormal movements in Sgcem+/pGt mice or if ≤ 1/3 scored abnormal movements in WT littermates.
*
p < 0.05.