Decreases in regional CBF with dementia. a Coronal slices display reduced hippocampal, caudate, and thalamic CBF in AD vs. MCI (right) and AD vs. no cognitive impairment (NCI) (left) groups on voxel-level comparison. b The thalamic CBF decreases by 20 % in AD compared to MCI individuals. c Thalamic CBF is associated with global cognitive impairment on the Dementia Rating Scale (DRS) in AD (red) and MCI (green). d Caudate CBF reduction is associated with increased white matter lesions (WMLs) severity across the NCI-MCI-AD spectrum. All ps < 0.05 after correcting for voxel-level multiple comparisons. NCI, n = 46; MCI, n = 23; AD, n = 12 (Modified from [39, 120]; images courtesy of Daniel Nation)