Table 1.
Increased Inflammatory cytokine/chemokine growth factors upon BCG or Ty21a infection of human bladder explants and/or urothelial cell lines.
| Human bladder 3D-assay (n = 9) |
RT4 (n = 3) |
RT112 (n = 3) |
||||
|---|---|---|---|---|---|---|
| Ty21aa | BCGa | Ty21ab | BCGb | Ty21ab | BCGb | |
| IL-1β | +++ | ++++ | ||||
| IL-10 | ++ | + | ||||
| IL-15 | + | +/− | ND | |||
| MIP-1α | +++ | ++ | ||||
| TNF-α | ++ | + | ||||
| IP-10 | +/− | + | ||||
| MIG | + | ++ | ||||
| IL1-RA | +/− | ∼ | ||||
| FGF-basic | +/− | +/− | +/− | +/− | ∼ | ∼ |
| IL-2R | +/− | + | ∼ | ∼ | ∼ | ∼ |
| Rantes | +/− | +/− | +++ | ND | ND | ND |
| IL-6 | +/− | +/− | ++++ | ++ | ++ | + |
| GM-CSF | +++ | + | +++ | ++ | ++ | +/− |
| IL-8 | ++ | + | ++ | + | ++++ | ++ |
| MIP-1β | ++ | ++ | + | ∼ | ND | ND |
| MCP-1 | + | +/− | +/− | ∼ | ++ | + |
| HGF | +/− | +/− | ∼ | ∼ | ++ | ++ |
| G-CSF | +/− | +/− | ++++ | ND | ND | ND |
| IFN-α | +/− | +/− | ∼ | ∼ | + | ND |
| IL-12 | +/− | +/− | + | +/− | + | +/− |
| VEGF | +/− | +/− | + | +/− | ++ | +/− |
| IL-7 | ∼ | ∼ | + | ∼ | ND | ND |
Geometric mean fold increases between Ty21a or BCG treated samples versus PBS are indicated:
∼ : 0.5–<1.3, +/−: 1.3–<2.5, +: 2.5–<4; ++: 4–<10; +++: 10–<20; ++++: >20. ND: not detected
a 2 × 106 CFU:, b moi 100.