Table 1.
Patients | % | Median mPD-L1 | p-value | Median PD-L1 mRNA | p-value | |
---|---|---|---|---|---|---|
All patients | 383 | 100 | −0.371 | 4.109 | ||
Missing data (methylation/mRNA expression) | 11/11 | 2.9/2.9 | ||||
Sex | ||||||
Female | 168 | 43.9 | −0.372 | 0.67* | 4.089 | 0.88* |
Male | 206 | 53.8 | −0.370 | 4.135 | ||
Unknown | 9 | 2.3 | ||||
Follow-up | ||||||
Patients with follow-up: OS | 364 | 95 | ||||
Events/deaths | 70 | 18.3 | ||||
Patients with follow-up: RFS | 313 | 82 | ||||
Events/recurrences | 60 | 15.7 | ||||
Mean follow-up [mo] | 24.5 [21.6–27.5] | |||||
Median follow-up [mo] | 13.7 | |||||
Range follow-up [mo] | 0.1–142.3 | |||||
Age [y] | ||||||
Mean | 64.4 [63.0–65.7] | |||||
Median | 66 | |||||
≤ 66 y | 193 | 50.4 | −0.365 | 0.023* | 3.924 | 0.066* |
> 66 y | 181 | 47.3 | −0.380 | 4.544 | ||
Unknown | 9 | 2.3 | ||||
pT category | ||||||
1 | 10 | 2.6 | −0.369 | 0.41** | 3.722 | 0.81** |
2 | 55 | 14.4 | −0.389 | 4.358 | ||
3 | 250 | 65.3 | −0.371 | 4.135 | ||
4 | 46 | 12 | −0.354 | 4.043 | ||
Unknown | 22 | 5.8 | ||||
pN category | ||||||
0 | 197 | 51.4 | −0.381 | <0.001* | 4.367 | 0.15* |
1 | 96 | 25.1 | −0.357 | 4.022 | ||
2 | 66 | 17.2 | −0.350 | 3.983 | ||
Unknown | 24 | 6.3 | ||||
M category | ||||||
0 | 242 | 63.2 | −0.375 | 0.002* | 4.313 | 0.045* |
1 | 48 | 12.5 | −0.351 | 3.734 | ||
Unknown | 93 | 24.3 | ||||
Microsatellite instability | ||||||
MSS | 258 | 67.4 | −0.372 | 0.54ε | 3.837 | <0.001ε |
MSI-L | 65 | 17.0 | −0.358 | 4.136 | ||
MSI-H | 55 | 14.4 | −0.371 | 5.545 | ||
Intermediate | 3 | 0.8 | −0.410 | 3.055 | ||
Unknown | 2 | 0.5 | ||||
BRAF | ||||||
Wildtype | 32 | 8.4 | −0.374 | 0.80* | 2.918 | 0.025* |
Mutation | 3 | 0.8 | −0.383 | 4.347 | ||
Unknown | 348 | 90.9 | ||||
KRAS | ||||||
Wildtype | 32 | 8.4 | −0.353 | 0.38* | 2.996 | 0.86* |
Mutation | 27 | 7.0 | −0.357 | 3.261 | ||
Unknown | 324 | 84.6 | ||||
MLH1 expression by IHC | ||||||
Absent | 58 | 15.1 | −0.368 | 0.94* | 3.810 | 0.014* |
Present | 176 | 46.0 | −0.370 | 4.482 | ||
Unknown | 149 | 38.9 |
Wilcoxon–Mann–Whitney U test.
Kruskal–Wallis test.
IHC: immunohistochemistry; OS: overall survival; RFS: recurrence free survival.