Table 2.
Overall survival |
Recurrence-free survival |
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---|---|---|---|---|---|---|---|---|---|---|
Univariate |
Multivariate (n = 256) |
Univariate |
Multivariate (n = 242) |
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Variable | n | p-value | Hazard Ratio [95% CI] | p-value | Hazard ratio [95% CI] | n | p-value | Hazard ratio [95% CI] | p-value | Hazard ratio [95% CI] |
Stratifying by age ≤ 66 y vs. age > 66 y* | ||||||||||
Sex (women vs. men) | 330 | 0.23 | 0.74 [0.45–1.21] | 0.76 | 1.09 [0.62–1.93] | 313 | 0.14 | 0.67 [0.39–1.14] | 0.93 | 0.97 [0.50–1.89] |
pT category | 318 | <0.001 | 3.96 [2.18–7.18] | 0.005 | 3.07 [1.40–6.72] | 301 | <0.001 | 3.70 [2.01–6.82] | 0.14 | 1.89 [0.81–4.40] |
pN category | 316 | <0.001 | 1.79 [1.36–2.38] | 0.34 | 1.23 [0.81–1.86] | 300 | <0.001 | 1.86 [1.34–2.57] | 0.98 | 1.01 [0.61–1.65] |
pM category | 258 | <0.001 | 5.40 [2.87–10.2] | 0.003 | 2.96 [1.45–6.05] | 243 | 0.001 | 3.76 [1.79–7.91] | 0.006 | 3.35 [1.41–7.94] |
MSI-H vs. non-MSI-H | 329 | 0.37 | 0.85 [0.60–1.21] | 0.76 | 0.93 [0.57–1.51] | 312 | 0.36 | 0.83 [0.56–1.23] | 0.69 | 0.90 [0.53–1.52] |
mPD-L1 | 319 | 0.003 | 21.1 [2.92–152] | 0.030 | 17.7 [1.33–225] | 302 | <0.001 | 35.3 [5.05–247] | <0.001 | 84.7 [7.85–915] |
PD-L1 mRNA | 330 | 0.44 | 0.94 [0.79–1.11] | 0.89 | 0.98 [0.78–1.24] | 313 | 0.35 | 0.91 [0.76–1.11] | 0.66 | 1.06 [0.82–1.37] |
Stratifying by age ≤ 66 y vs. age > 66 y.
Overall survival: 13 events/127 censored (age ≤ 66 y), 38 events/78 censored (age > 66 y:); recurrence-free survival: 20 events/113 censored (age ≤ 66 y), 21 events/88 censored (age > 66 y).