Table 2.

Univariate and multivariate Cox proportional hazard analyses of overall survival and recurrence-free survival in patients with CRC. Bold numbers indicate statistically significant correlations with p-values less than 0.05.

	Overall survival					Recurrence-free survival
	Univariate			Multivariate (n = 256)		Univariate			Multivariate (n = 242)
Variable	n	p-value	Hazard Ratio [95% CI]	p-value	Hazard ratio [95% CI]	n	p-value	Hazard ratio [95% CI]	p-value	Hazard ratio [95% CI]
Stratifying by age ≤ 66 y vs. age > 66 y*
Sex (women vs. men)	330	0.23	0.74 [0.45–1.21]	0.76	1.09 [0.62–1.93]	313	0.14	0.67 [0.39–1.14]	0.93	0.97 [0.50–1.89]
pT category	318	<0.001	3.96 [2.18–7.18]	0.005	3.07 [1.40–6.72]	301	<0.001	3.70 [2.01–6.82]	0.14	1.89 [0.81–4.40]
pN category	316	<0.001	1.79 [1.36–2.38]	0.34	1.23 [0.81–1.86]	300	<0.001	1.86 [1.34–2.57]	0.98	1.01 [0.61–1.65]
pM category	258	<0.001	5.40 [2.87–10.2]	0.003	2.96 [1.45–6.05]	243	0.001	3.76 [1.79–7.91]	0.006	3.35 [1.41–7.94]
MSI-H vs. non-MSI-H	329	0.37	0.85 [0.60–1.21]	0.76	0.93 [0.57–1.51]	312	0.36	0.83 [0.56–1.23]	0.69	0.90 [0.53–1.52]
mPD-L1	319	0.003	21.1 [2.92–152]	0.030	17.7 [1.33–225]	302	<0.001	35.3 [5.05–247]	<0.001	84.7 [7.85–915]
PD-L1 mRNA	330	0.44	0.94 [0.79–1.11]	0.89	0.98 [0.78–1.24]	313	0.35	0.91 [0.76–1.11]	0.66	1.06 [0.82–1.37]

^*Stratifying by age ≤ 66 y vs. age > 66 y.

Overall survival: 13 events/127 censored (age ≤ 66 y), 38 events/78 censored (age > 66 y:); recurrence-free survival: 20 events/113 censored (age ≤ 66 y), 21 events/88 censored (age > 66 y).