Table 2. Cox regression model analysis for prognosis based on various clinical characteristics of NSCLC patients.

Factor	HR	95% CI (univariate)	P value	miR-33a multivariate analysis
				HR	95% CI (multivariate)	P value
Age	0.95	0.71–1.15	0.78
Gender	0.88	0.54–1.26	0.36
Smoking history	1.22	0.73–1.38	0.12
Lymph-node metastasis	1.54	1.16–1.86	0.04	1.78	1.20–2.66	0.02
Tumor differentiation	0.78	0.54–1.11	0.16
Histology	1.19	0.88–1.24	0.11
TNM stage	2.29	2.72–3.38	0.01	2.43	1.86–2.98	0.008
Invasion of lung membrane	1.76	1.45–1.99	0.02
Vascular invasion	0.91	0.68–1.24	0.75
Diameter (≥ 5 cm)	2.56	2.03–3.45	0.001	3.17	2.26–5.03	<0.001
Low miR-33a expression	1.66	1.21–2.24	0.028