Table 1.
MIC of teixobactin homologues in µg/mL.
|
Staphylococcus epidermidis ATCC 14990 |
Streptococcus salivarius ATCC 13419 |
Enterococcus durans ATCC 6056 |
Bacillus subtilis ATCC 6051 |
Escherichia coli ATCC 10798 |
|
|---|---|---|---|---|---|
| Arg10-teixobactin | 1 | 1 | 4 | 2 | >32 |
| Lys10-teixobactin | 0.25 | 0.5 | 1 | 0.5 | >32 |
| l-Thr8,Arg10-teixobactin | >32 | >32 | >32 | >32 | >32 |
| d-allo-Ile11,Arg10-teixobactin | 2 | 2 | 8 | 4 | >32 |
| seco-Arg10-teixobactin | >32 | >32 | >32 | >32 | >32 |
| ent-Arg10-teixobactin | 2 | 1 | 4 | 2 | >32 |
| short-Arg10-teixobactin | >32 | >32 | >32 | >32 | >32 |
| lipobactin 1 | 4 | 4 | 8 | 4 | >32 |
| vancomycin | 0.5 | 0.5 | 0.5 | 1 | >32 |
| teixobactin1 | 0.08–0.3 | 0.02–0.15 | 0.3–0.6 | 0.02–0.6 | 25 |
| various Staphylococcus1 |
various Streptococcus1 |
various Enterococcus1 |
various Bacillus1 |
E. coli1 | |