Figure 2. Transgenic mouse model demonstrating the effect of doxycline induction of mutant B-Raft in thyroid cells. Note that within a week of induction of the driver oncogene, the cadre of proteins responsible for uptake of radioiodine are rapidly down regulated, as the effect of the driver oncogene takes hold. If the doxycline is stopped, this effect can be ameliorated, and it is the sodium iodine symporter protein, of Na+/I- symporter, that responds most quickly (from reference 1).