Table 1. Postnatal tolerance induction following AAV.GFP IUGT.
Animal # | GA @ IUGT (days) | AAV serotype | Concentration (GC) | GA @ birth (days) | Hepatic GFP expression |
---|---|---|---|---|---|
2003 | 64 | 8 | 8.69x1011 | 144 | Yes |
465 | 62 | 6.2 | 1.64x1011 | 146 | Yes |
GA, gestational age; IUGT, in utero gene transfer; GC, genome copies; Hepatic GFP expression assessed at 1 month postnatal age prior to postnatal GFP and AAV vector challenge.