Table 1. Nucleotide sequence mutation at E6/E7 of 15 HPV 33 isolates.
| sequence pattern | HPV33 E6 | HPV33 E7 | n (216) | sub-lineages | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2 | 2 | 3 | 3 | 3 | 4 | 5 | 5 | 6 | 7 | 8 | |||
| 1 | 7 | 2 | 6 | 8 | 4 | 4 | 4 | 5 | 0 | 6 | |||
| 3 | 3 | 9 | 4 | 7 | 6 | 2 | 9 | 8 | 6 | 2 | |||
| M12732 | A | A | G | A | A | A | G | T | G | C | A | ||
| 33HE01 | - | - | - | - | - | - | - | - | - | - | - | 104 | A1 |
| 33HE02 | - | - | - | - | - | - | - | - | C | - | - | 3 | A1 |
| 33HE03 | - | - | - | - | - | - | - | - | C | T | - | 1 | A1 |
| 33HE04 | - | - | - | - | - | - | - | - | - | T | - | 31 | A1 |
| 33HE05 | - | - | - | - | - | - | T | - | - | T | - | 4 | A1 |
| 33HE06 | - | - | - | - | - | - | T | - | - | - | - | 16 | A1 |
| 33HE07 | - | - | - | - | - | - | T | - | - | - | T | 1 | A1 |
| 33HE08 | - | - | - | - | - | - | T | - | C | - | T | 1 | A1 |
| 33HE09 | - | - | - | - | - | - | T | - | C | - | - | 4 | A1 |
| 33HE10 | - | - | C | - | - | - | T | - | C | - | - | 7 | A1 |
| 33HE11 | - | - | - | - | - | - | - | - | - | A | - | 1 | A1 |
| 33HE12 | - | - | - | - | C | - | - | - | - | A | - | 1 | A1 |
| 33HE13 | C | - | - | - | C | - | - | C | - | A | - | 25 | A1 |
| 33HE14 | C | G | - | - | - | - | - | - | - | - | T | 1 | A3 |
| 33HE15 | C | G | - | C | C | G | - | - | - | - | T | 16 | A3 |
| aa mutation | Q | R | |||||||||||
| K | S | N | K | 1 | 1 | S | A | Q | |||||
| 3 | - | 7 | 8 | 9 | 1 | 4 | - | 2 | 4 | 9 | |||
| 5 | 4 | 6 | 3 | 3 | 5 | 9 | 5 | 7 | |||||
| N | T | H | N | R | I | T | V/E | L | |||||
| second structure | - | S | H | - | - | H | - | - | - | - | - | ||
The nucleotides conserved with respect to the reference sequence were marked with a dash (-), whereas a variation position was indicated by a letter. The “S” in the last row of the table means Sheet, the “H” means Helix. “n” represents the number of each sequence pattern among the 216 samples examined.