Table 2. Association of APOBEC3B mRNA in matched primary tumors and their metastasis according metastatic site.
| APOBEC3B mRNA log2 | AVG epithelial mRNA log2 | PTPRC (CD45) mRNA log2 | ||||||
|---|---|---|---|---|---|---|---|---|
| Clinical parameter | No of patients* | Percentage of patients | Mean | SD | Mean | SD | Mean | SD |
| Tissue origin | ||||||||
| Primary tumor | 55 | 100% | -6.51 | 2.53 | -3.04 | 1.07 | -3.98 | 3.23 |
| Paired Metastasis | 55 | 100% | -5.36 | 2.39 | -2.85 | 1.08 | -4.48 | 2.84 |
| Pǂ | 0.0015 | 0.20 | 0.26 | |||||
| According metastatic site | ||||||||
| Loco-regional lymph node | ||||||||
| Primary tumor | 20 | 36% | -6.87 | 2.55 | -2.82 | 0.91 | -3.88 | 2.89 |
| Paired Metastasis | 20 | 36% | -6.12 | 2.68 | -2.63 | 0.89 | -3.42 | 3.03 |
| Pǂ | 0.23 | 0.31 | 0.49 | |||||
| Distant metastases | ||||||||
| Primary tumor | 35 | 64% | -6.30 | 2.54 | -3.16 | 1.15 | -4.30 | 3.34 |
| Paired Metastasis | 35 | 64% | -4.93 | 2.13 | -2.98 | 1.16 | -4.82 | 2.80 |
| Pǂ | 0.002 | 0.38 | 0.39 | |||||
| Distant metastasis specified | ||||||||
| Ovary | ||||||||
| Primary tumor | 4 | 7% | -9.25 | 1.39 | -3.31 | 1.25 | -5.53 | 5.25 |
| Paired Metastasis | 4 | 7% | -5.51 | 0.74 | -3.03 | 1.20 | -3.99 | 0.93 |
| Pǂ | 0.07 | 0.72 | 0.47 | |||||
| GI tract | ||||||||
| Primary tumor | 3 | 5% | -7.79 | 3.84 | -3.32 | 0.20 | -1.83 | 1.10 |
| Paired Metastasis | 3 | 5% | -6.96 | 0.54 | -3.93 | 1.88 | -4.41 | 4.88 |
| Pǂ | 0.59 | 0.59 | 0.11 | |||||
| Liver | ||||||||
| Primary tumor | 6 | 11% | -7.59 | 2.65 | -3.16 | 1.57 | -2.66 | 1.35 |
| Paired Metastasis | 6 | 11% | -5.10 | 2.45 | -2.20 | 1.17 | -4.76 | 2.71 |
| Pǂ | 0.08 | 0.17 | 0.028 | |||||
| Bone | ||||||||
| Primary tumor | 4 | 7% | -5.82 | 1.23 | -3.01 | 1.28 | -5.04 | 3.31 |
| Paired Metastasis | 4 | 7% | -4.98 | 3.85 | -2.63 | 0.96 | -4.11 | 3.97 |
| Pǂ | 0.47 | 0.27 | 0.47 | |||||
| Brain | ||||||||
| Primary tumor | 14 | 25% | -5.29 | 2.06 | -3.10 | 1.03 | -5.53 | 3.58 |
| Paired Metastasis | 14 | 25% | -4.46 | 2.00 | -2.95 | 0.81 | -5.67 | 2.82 |
| Pǂ | 0.20 | 0.68 | 0.98 | |||||
| Lung | ||||||||
| Primary tumor | 4 | 7% | -4.32 | 1.45 | -3.29 | 1.69 | -2.35 | 1.59 |
| Paired Metastasis | 4 | 7% | -4.21 | 1.49 | -3.82 | 1.47 | -3.76 | 1.66 |
| Pǂ | 0.72 | 0.47 | 0.14 | |||||
SD; standard deviation. AVG epithelial; average mRNA level of KRT19 and EPCAM.
* Due to missing values, numbers don’t always add up to 55.
ǂ Paired Wilcoxon Signed Ranks Test significance (2-tailed).