Table 2. Effect of green tea polyphenol intake on cytoplasmic HuR expression.
| Uni-variate analyses | Multi-variate analyses* | |||||
|---|---|---|---|---|---|---|
| OR | 95% CI | P value | OR | 95% CI | P value | |
| For large tumor | ||||||
| GTP: intake | 0.31 | 0.10–0.98 | 0.050 | |||
| GTP: 24 wks | 22.2 | 2.48–190.0 | 0.005 | 23.1 | 0.84–634.1 | 0.063 |
| C-HuR: positive | 4.96 | 1.88–13.1 | 0.001 | 4.07 | 0.84–19.63 | 0.081 |
| For high MVD | ||||||
| GTP: intake | 0.37 | 0.12–1.16 | 0.088 | |||
| GTP: 24 wks | 8.07 | 1.56–41.7 | 0.013 | 3.04 | 0.45–20.18 | 0.252 |
| C-HuR: positive | 2.84 | 1.41–5.72 | 0.004 | 1.78 | 0.81–3.94 | 0.153 |
| For high PI | ||||||
| GTP: intake | 0.26 | 0.08–0.84 | 0.025 | 0.72 | 0.13–4.01 | 0.704 |
| GTP: 24 wks | 4.38 | 1.03–18.6 | 0.045 | 0.93 | 0.13–6.86 | 0.944 |
| C-HuR: positive | 3.85 | 1.67–8.90 | 0.002 | 2.55 | 0.87–7.44 | 0.087 |
| For COX-2 | ||||||
| GTP: intake | 0.12 | 0.03–0.44 | 0.001 | 0.21 | 0.05–0.91 | 0.037 |
| GTP: 24 wks | 1.41 | 0.39–5.05 | 0.559 | |||
| C-HuR: positive | 4.46 | 1.65–12.1 | 0.003 | 1.52 | 1.10–8.71 | 0.033 |
| For VEGF-A | ||||||
| GTP: intake | 0.51 | 0.17–1.59 | 0.249 | |||
| GTP: 24 wks | 2.65 | 0.69–10.2 | 0.156 | |||
| C-HuR-positive | 3.85 | 1.67–8.90 | <0.001 | 2.83 | 1.11–7.20 | 0.029 |
| For HO-1 | ||||||
| GTP: intake | 0.15 | 0.04–0.53 | 0.003 | 0.24 | 0.06–0.96 | 0.043 |
| GTP: 24 wks | 1.92 | 0.54–6.87 | 0.318 | |||
| C-HuR: positive | 2.47 | 1.23–4.94 | 0.011 | 1.62 | 0.78–3.35 | 0.194 |
* Adjusted by cancer cell invasion
HuR; human antigen R, OR; odds ratio, CI; confidential interval, GTP; green tea polyphenol, wks; weeks, C; cytoplasmic, MVD; microvessel density, PI; proliferation index, COX; cyclooxygenase, VEGF; vascular endothelial growth factor, HO; hemeoxygenase.