Table 4.
Study population urine study characteristics by category of baseline estimated glomerular filtration rate (mL/min/1.73 m2)a
| Characteristic | < 15 | 15 ≤ 30 | 30 ≤ 45 | 45 ≤ 60 | Total No. | p value |
|---|---|---|---|---|---|---|
| Population, no. (%) | 23 (0.2) | 178 (1.4) | 1443 (11.6) | 10,750 (86.7) | 12,394 (100.0) | |
| Proteinuria,b no. (%) | 3 (13) | 31 (17.4) | 141 (9.8) | 207 (1.9) | 382 (3.1) | < 0.001 |
| Urine protein quantification, no. (%) | 4 (17.4) | 42 (23.6) | 308 (21.3) | 1248 (11.6) | 1602 (12.9) | < 0.001 |
| 24-hour urinary total protein (g) | ||||||
| No. of patients | 0 | 3 | 6 | 14 | 23 | 0.061 |
| Mean (SD) | — | 495.0 (314.42) | 1064.5 (1836.40) | 525.7 (1369.56) | 662.3 (1394.13) | |
| Median (interquartile range) | — | 594.0 (143.0–748.0) | 354.0 (192.0–564.0) | 104.0 (77.0–192.0) | 150.0 (81.0–564.0) | |
| Range | — | 143.0–748.0 | 123.0–4800.0 | 5.0–5238.0 | 5.0–5238.0 | |
| Urine protein-to-creatinine ratio (mg/mg creatinine) | ||||||
| No. of patients | 2 | 18 | 49 | 72 | 141 | < 0.001 |
| Mean (SD) | 2.1 (0.0) | 2.2 (2.56) | 1.0 (1.81) | 0.5 (0.97) | 0.9 (1.64) | |
| Median (interquartile range) | 2.1 (2.1–2.1) | 1.5 (0.5–2.5) | 0.4 (0.1–0.8) | 0.1 (0.1–0.5) | 0.3 (0.1–1.1) | |
| Range | 2.1–2.1 | 0.3–10.2 | 0.0–8.6 | 0.0–3.8 | 0.0–10.2 | |
| Albumin-to-creatinine ratio (mg/mg albumin) | ||||||
| No. of patients | 3 | 31 | 234 | 613 | 881 | < 0.001 |
| Mean (SD) | 1.7 (1.56) | 0.9 (1.03) | 0.4 (0.95) | 0.2 (0.58) | 0.2 (0.74) | |
| Median (interquartile range) | 2.0 (0.0–3.1) | 0.4 (0.1–1.5) | 0.0 (0.0–0.2) | 0.0 (0.0–0.0) | 0.0 (0.0–0.1) | |
| Range | 0.0–3.1 | (0.0–4.7) | 0.0–8.3 | 0.0–7.7 | 0.0–8.3 | |
| Hematuriac | 0/3 (0.0) | 4/22 (18.2) | 40/135 (29.6) | 144/458 (31.4) | 188/618 (30.4) | 0.371 |
| Any urine study,d no. (%) | 4 (17.4) | 42 (23.6) | 313 (21.7) | 1260 (11.7) | 1619 (13.1) | < 0.001 |
For those with confirmed chronic kidney disease (second estimated glomerular filtration rate [eGFR] < 60 mL/min/1.73 m2), the proportion with a urine test of any kind within 180 days of the second eGFR is 32.0%. In total, 1619 out of the 6980 patients with a repeated measurement had any urine test of any kind within 180 days of that measurement.
Proteinuria is defined as meeting any of the following criteria: urine microalbumin-to-creatinine ratio > 30 mg/g, urine protein-to-creatinine ratio > 0.2, 24-hour urine protein concentration > 200 mg, 24-hour urine albumin level > 30 mg, or urinanlysis with 2+ or higher protein.
Hematuria is defined as any urine dipstick result that was 1+ or higher for blood or urine microscopy reporting 5 or greater red blood cells per high-power field. Numbers are reported as number of patients with hematuria over total number with available laboratory measurement (and percentage).
Within 6 months of the follow-up creatinine measurement. SD = standard deviation.