Table 6.
Study population characteristics classified by whether patients were captured by the Modification Diet in Renal Diseases (MDRD) equation alone or by both MDRD and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equationsa
| Characteristic | MDRD only | MDRD and CKD-EPI | Total | p value |
|---|---|---|---|---|
| Population | 4732 (43.5) | 6154 (56.5) | 10,886 (100.0) | |
| Female sex | 2464 (52.1) | 3007 (48.9) | 5471 (50.3) | 0.001 |
| Follow-up MDRD eGFR (mL/min/m2) | ||||
| Mean (SD) | 66.7 (11.49) | 55.2 (14.80) | 60.0 (14.66) | < 0.001 |
| < 15 | 0 (0.0) | 21 (0.6) | 21 (0.3) | |
| 15 ≤ 30 | 7 (0.3) | 96 (2.6) | 103 (1.6) | |
| 30 ≤ 45 | 31 (1.2) | 661 (18.1) | 692 (11) | |
| 45 ≤ 60 | 788 (29.6) | 1695 (46.5) | 2483 (39.4) | |
| > 60 | 1832 (68.9) | 1174 (32.2) | 3006 (47.7) | |
| Demographics | ||||
| Age at index date (years) | ||||
| Mean (SD) | 43.2 (8.54) | 54.7 (12.55) | 49.7 (12.40) | < 0.001 |
| 18–39 | 1354 (28.6) | 692 (11.2) | 2046 (18.8) | |
| 40–64 | 3366 (71.1) | 4164 (67.7) | 7530 (69.2) | |
| 65–85 | 12 (0.3) | 1214 (19.7) | 1226 (11.3) | |
| > 85 | 0 (0.0) | 84 (1.4) | 84 (0.8) | |
| Race/ethnicity | ||||
| White, non-Hispanic | 2287 (48.3) | 3360 (54.6) | 5647 (51.9) | < 0.001 |
| Black, non-Hispanic | 757 (16) | 442 (7.2) | 1199 (11) | |
| Hispanic | 870 (18.4) | 1151 (18.7) | 2021 (18.6) | |
| Asian, non-Hispanic | 321 (6.8) | 470 (7.6) | 791 (7.3) | |
| Other, non-Hispanic | 497 (10.5) | 731 (11.9) | 1228 (11.3) | |
| Charlson Comorbidity Index | ||||
| 0 | 3261 (68.9) | 2512 (40.8) | 5773 (53) | < 0.001 |
| 1–2 | 1369 (28.9) | 2689 (43.7) | 4058 (37.3) | |
| ≥ 3 | 102 (2.2) | 951 (15.5) | 1053 (9.7) | |
| Any urinalysis laboratory test or procedure | 427 (9) | 1146 (18.6) | 1573 (14.4) | < 0.001 |
| Previous comorbidities | ||||
| Hypertension | 844 (17.8) | 2778 (45.1) | 3622 (33.3) | < 0.001 |
| Diabetes mellitus | 150 (3.2) | 801 (13) | 951 (8.7) | < 0.001 |
| History of systemic lupus | 0 (0.0) | 4 (0.1) | 4 (0.0) | 0.079 |
| Stroke | 53 (1.1) | 213 (3.5) | 266 (2.4) | < 0.001 |
| Congestive heart failure | 22 (0.5) | 99 (1.6) | 121 (1.1) | < 0.001 |
| Outcomes | ||||
| All-cause mortality | 15 (0.3) | 242 (3.9) | 257 (2.4) | < 0.001 |
| End-stage renal disease | 5 (0.1) | 72 (1.2) | 77 (0.7) | |
| Length of follow-up | ||||
| Mean (SD) | 3.8 (1.76) | 3.8 (1.85) | 3.8 (1.81) | 0.862 |
| Median (interquartile range) | 3.7 (2.5–4.7) | 3.6 (2.5–4.9) | 3.7 (2.5–4.8) | |
| Range | 0.1–9.0 | 0.0–9.0 | 0.0–9.0 | |
a
On the basis of the patient’s initial serum creatinine measurement. Data are presented as no. (%) unless indicated otherwise.
eGFR = estimated glomerular filtration rate; SD = standard deviation.