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. 2016 Dec 8;16(2):189–199. doi: 10.1080/15384101.2016.1261765

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© 2017 The Author(s). Published with license by Taylor & Francis

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 3. — Tumor cells continue to progress in S-phase despite low nucleosome levels induced by CASP8AP2 knockdown. (A, B) Flow cytometry analysis of DNA content, DNA replication and histone H3 levels in siRNA treated cells. Note that tumor cells continue to replicate their DNA slowly (A) for multiple days, despite low amount of histone H3 (red arrowheads) (B). (C, D) Flow cytometry analysis of DNA content, DNA replication (EdU staining) and histone H3 levels in siRNA treated hTERT-RPE1 cells. Note that normal cells arrest in S-phase (C), and show decrease in histone H3 levels in early S-phase (red arrowheads) (D).