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. Author manuscript; available in PMC: 2017 Jan 31.
Published in final edited form as: Biotechnol Bioeng. 2016 Sep 21;113(11):2403–2415. doi: 10.1002/bit.26017

Scheme 1. Schematic diagram of polyamine pathway and regulation of ornithine decarboxylase (ODC) by antizyme (OAZ) and antizyme inhibitor (AZIN).

Scheme 1

Simplified pathway of polyamine synthesis from ornithine is indicated by solid arrows and polyamine catabolism by broken arrows. ODC is regulated by OAZ whose translation is turned on by +1 ribosomal frame shifting at a high concentration of polyamines. OAZ is in turn regulated by AZIN, which is an ODC-like protein, but devoid of the enzyme activity.