Fig. 11.
Amiloride-sensitive currents in Sgk1+/+ and Sgk1−/− mice. A: whole cell currents ± amiloride (10 μM) from a principal cell of a CCD in an Sgk1+/+ mouse fed a high-K diet. B: current-voltage (I-V) relationships for the cell in A. INa represents amiloride-sensitive currents. C: whole cell currents ± amiloride (10 μM) from a principal cell of a CCD in an Sgk1−/− mouse fed a high-K diet. D: I-V relationships for the cell in C. E: whole cell currents ± amiloride (10 μM) from a principal cell of a CNT from an Sgk1+/+ mouse infused with aldosterone (12 μg/day). F: I-V relationships for the cell in E. G: whole cell currents ± amiloride (10 μM) from a principal cell of a CNT from an Sgk1−/− infused with aldosterone (12 μg/day). H: I-V relationships for the cell in G. I: quantitation of amiloride-sensitive currents measured at a −100 mV. Data are represented as means ± SE for 7–24 cells.