Fig. 1.

Analysis of running performance of wild-type (WT) and obscurin (Obs) knockout (KO) mice under different exercise protocols. A low-intensity running protocol revealed that WT and obscurin KO mice have comparable exercise endurance under mild training conditions (A) (see materials and methods for training parameters). Conversely, a markedly reduced performance of obscurin KO mice on the treadmill is induced by higher exercise intensity (running at exhaustion) and progressively worsens with the increasing age of trained mice (B–D). P values are shown.