Table 1.
Morphological parameters and cardiac output
| Sham | Sham + ICI | ACF | ACF + ICI | |
|---|---|---|---|---|
| 5 days postsurgery | n = 6 | n = 5 | n = 7 | n = 5 |
| BW, g | 217 ± 4 | 227 ± 2 | 202 ± 8 | 199 ± 3 |
| LV/BW, mg/g | 2.43 ± 0.11 | 2.54 ± 0.04 | 2.72 ± 0.15 | 2.90 ± 0.13* |
| RV/BW, mg/g | 0.62 ± 0.02 | 0.60 ± 0.03 | 0.83 ± 0.08* | 0.81 ± 0.05* |
| Lung/BW, mg/g | 5.67 ± 0.09 | 5.74 ± 0.03 | 6.12 ± 0.51 | 6.87 ± 0.30* |
| 6 wk postsurgery | n = 8 | n = 6 | n = 8 | n = 7 |
| CO, ml/min | 31.1 ± 2.4 | 28.5 ± 2.7 | 110 ± 12* | 108 ± 11* |
| BW, g | 242 ± 21 | 228 ± 3 | 242 ± 4 | 245 ± 16 |
| LV/BW, mg/g | 2.40 ± 0.11 | 2.29 ± 0.06 | 4.11 ± 0.07* | 4.06 ± 0.09* |
| RV/BW, mg/g | 0.59 ± 0.02 | 0.60 ± 0.02 | 1.19 ± 0.07* | 1.26 ± 0.07* |
| Lung/BW, mg/g | 5.72 ± 0.20 | 5.51 ± 0.20 | 6.67 ± 0.18* | 7.40 ± 0.18*† |
| Uterus/BW, mg/g | 2.54 ± 0.40 | 2.04 ± 0.15 | 2.25 ± 0.24 | 1.85 ± 0.18 |
Values are means ± SD. BW, body weight; Sham, sham-operated control; ICI, estrogen receptor antagonist ICI-182,780; ACF, aortocaval fistula volume overloaded; LV, left ventricle; RV, right ventricle; CO, cardiac output.
*
P < 0.05 vs. Sham;
†
P < 0.05 vs. ACF.