Fig. 1.

Cardiac function is progressively depressed with hyperglycemia. A: M-mode echocardiographic images for one naïve male FVB mouse control (Ctrl; left) and one streptozotocin (STZ)-treated male FVB mouse ~5 mo after induction of diabetes (right). LV, left ventricular. B: echocardiographic parameters obtained on a monthly basis in naïve male FVB mice (Ctrl, n = 46, 26, 28, 17, and 12 at 1, 2, 3, 4, and 5 mo, respectively) and STZ-treated male FVB mice (STZ, n = 50, 27, 25, 12, and 6 at 1, 2, 3, 4, and 5 mo after induction of diabetes, respectively) are shown as median and interquartile ranges. Analysis was performed in restrained, conscious mice. *P < 0.05 vs. Ctrl for the same time point using pairwise comparison. P < 0.001 refers to results of analysis of variance for multiple groups.