Table 2.
Genes and processes involved in each of the 8 major C/EBP binding patterns from Fig. 3
| Group | Genes, n | Description | Select Genes | Processes/Functions |
|---|---|---|---|---|
| 1 | 819 | Novel C/EBP-α regulation | Pdcd4, Sv2c, Mmp9, Clic4, Col1a1, Irak4, Raf1, Tnnt2, Mapk6, Chd2, Hpgd, Tlbp2, Tlbp4, Pdgfrb | Tgfb signaling pathway, regulation of cell growth, cell adhesion, kinase regulator activity, cell fraction, membrane, phosphorylation |
| 2 | 1,271 | Novel C/EBP-β regulation | Cebpg, Cebpe, Egf, Car2, Adamts1, Ak3l1, Casp12, Ccr7, Chd1, Col3a1, Cyp39a1, Edn1, Igfbp1, Lrat, Lum, Nt5e, Sparc, Tlr3, Mmp12, Traf6 | Regulation of protein kinase cascade, fat cell differentiation, response to wounding, regulation of homeostatic process, positive regulation of apoptosis, cell fraction, regulation of biosynthetic process |
| 3 | 371 | Novel C/EBP-α and C/EBP-β regulation | Tgfb3, Mapk1, Fos, Egr3, Il7, Tnsf11 | Cell proliferation, cell-cell signaling, regulation of kinase activity, |
| 4 | 2,223 | Missing C/EBP-β regulation | Nfkb2, Nod2, Rbpj, Vcam1, Sox1, Sox2, Vegfc, Anxa5, Bcl10, Acvr1b, Aimp1, Alox12, Anxa1, Ccne1, Ch25h, E2f1, E2f3, Itga1, Sulf2, Usp14, C6, C9, Faslg | Apoptosis, cellular protein catabolic process, fatty acid metabolic process, glycolysis |
| 5 | 570 | Transition of regulation from C/EBP-β to C/EBP-α | Cebpa, Tgfa, Tm4 sf1, Gcnt2, Nf1, Pdgfb, Jak2, Smad4 | Cell motion, cell migration, regulation of cellular biosynthetic process, cell fraction, phosphoprotein |
| 6 | 1,133 | Maintained C/EBP-β regulation | Jun, Ctgf, Hif1a, Atr, Prkcb | Phosphatase activity, homeostatic process, cell fraction, cell projection, cell adhesion, ATP metabolic process, ion binding |
| 7 | 1,194 | Deficient C/EBP-β baseline regulation/Ethanol-induced C/EBP-α regulation | Tgfb2, Npy, Ets2, Bach1, Npas2, Ntf3, Avpr1a, Bcl6, Ccrn4l, Cxcl12, Cyp2681, Ifng, Il15, App, Cd24 | Regulation of apoptosis, cell adhesion, cell-cell signaling, cAMP-mediated signaling, protein kinase activity, cell growth, membrane, ion binding |
| 8 | 606 | Deficient C/EBP-β baseline regulation/Maintained C/EBP-β and C/EBP-α response to PHx | Tgif1, Smad3, Ccnd2, Fgfr2, Lama1, Rxra, Tgfbr2 | Cell morphogenesis, regulation of cell proliferation, transcription repressor activity |