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. 2016 Oct 27;49(1):27–36. doi: 10.1152/physiolgenomics.00072.2016

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Fig. 5. — Comparison of 5-HT-mediated inhibition of spontaneous transient outward currents (STOCs) in VSMCs isolated from MCA of FHH and FHH.1^BN rats. STOCs were recorded at a V_h of +20 mV using perforated patch clamp method over a period of 7–10 min. A: traces of STOCs in the presence of 5-HT alone (3 μM) or combined with paxilline (100 nM). B and C: bar graph of STOC amplitude and frequency (n = 5–7 cells) measured before (pre-5-HT) and after (<5 min and between 7 and 10 min) application of 5-HT alone and combined with paxilline. *Region from where the amplitude and frequency of STOCs were measured. !Significant difference in the corresponding values before 5-HT application in FHH and FHH.1^BN rats. Error bars ± SE. Numbers in parentheses indicate the number of VSMCs studied.