Fig. 3.

Whole-lobe montages, segmented and analyzed by image cytometry, are shown for the cardiac lobe in a nonsurgical control and postpneumonectomy days 3, 7, and 14. A: a representative section of the midcardiac lobe is shown. B: regions of the pleura and subpleural regions are magnified. C: for each cardiac lobe, the frequency of SMA⁺ cells was plotted as a function of the distance from the pleura; the modal distribution of N = 5 animals is shown for Control, POD 3, and POD 7 time points; N = 3 for POD 14. Pleural SMA⁺ cells increased on day 3 with progressive increase in SMA⁺ cells in the subpleural and central regions. Note the increase in the size of the cardiac lobe, reflecting compensatory growth, on day 14. Bar = 200 µm.