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. 2016 Dec 2;312(1):L122–L130. doi: 10.1152/ajplung.00301.2016

Fig. 1.

Fig. 1.

Lung and airway inflammation and airway wall fibrosis induced by Ad-IL-1β is dependent on IL-17RA/IL-17A. Wild-type (WT) or il17ra-deficient (il17ra−/−) mice were treated with intratracheal Ad-IL-1β or Ad-LacZ, as a control (A–E). After 14 days, bronchoalveolar lavage (BAL) was performed and total cell counts (A), macrophage (B), or neutrophil numbers (C) were assessed. Morphometric analysis of airway inflammation (D) or airway wall fibrosis (E) was performed from histological sections. WT mice treated with anti-IL-17RA (F–J), or anti-IL-17A (K–O) underwent the same BAL and morphometric analysis. Experiments were repeated a minimum of 3 times with at least 3 mice/group. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.