Fig. 4.

Airway wall inflammation and fibrosis induced by CS+PIC is dependent on IL-17RA/IL-17A. WT (A, C, E) or il17ra^−/− mice (B, D, F) were treated with RA (A, B) or CS+PIC (C–F). After 21 days, lungs were harvested and assessed histologically by H&E (A–D) or Trichrome staining (E, F). WT mice were treated with RA (G, H, M, N) or CS+PIC (I–L, O–R) and treated with isotype control (G, I, K, M, O, Q), anti-IL-17RA (H, J, L) or anti-IL-17A (N, P, R). After 21 days airway inflammation and fibrosis were assessed by H&E (G–J, M–P) or Trichrome staining (K, L, Q, R). Experiments were repeated a minimum of 3 times with at least 3 mice/group. Bar = 100 μm.