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. 2016 May 4;76(2):427–434. doi: 10.1136/annrheumdis-2015-208953

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Regulatory mechanisms of the BATF (basic leucine zipper transcription factor, ATF-like)/JUN complex affecting catabolic and anabolic gene expression in chondrocytes. (A and B) Chromatin immunoprecipitation (ChIP) assay for binding of BATF, JUN-B or C-JUN in chondrocytes infected with Ad-Batf (800 MOI). Normal rabbit IgG was used as the negative control (n≥4). (C) Whole-cell lysates from chondrocytes infected with Ad-Batf (800 MOI) were co-immunoprecipitated with anti-C-FOS antibody or control IgG, and immunoblotted with anti-C-JUN antibody. (D) Western blot of IRF4 in chondrocytes stimulated with interleukin (IL)-1β, IL-6 and tumour necrosis factor (TNF)-α or infected with Ad-Batf. (E) ChIP assay for IRF4-binding in chondrocytes infected with Ad-Batf (n≥4).