Figure 3.

Apelin modulates duodenal glucose absorption. (A) Ex vivo glucose absorption in duodenal everted sacs in response to Krebs–Ringer (Control), apelin 100 nM, apelin 1 µM, F13A alone or with apelin 100 nM. n=5–7 per group. *p<0.05, **p<0.01. (B) Ex vivo apelin absorption in duodenal everted sacs in response to Krebs–Ringer (Control), apelin 100 nM or 1 µM, and F13A alone or F13A plus apelin 100 nM. n=4–6 per group. (C) In vivo measurement of plasma apelin in portal vein, in response to oral gavage of H₂O (Control), apelin 100 nM or apelin 1 µM. n=5–6 per group.