Table 2.

Pharmacokinetic parameters for lymphocyte glutathione (GSH) levels following the oral administration of 2 or 4 g γ-glutamylcysteine (γ-GC).

Subject	C0	2 g γ-GC
		Cmax	Cmax/C0	tmax	AUC	ΔAUC	Half-life (h)
				(h)
12M	0.443	0.597	1.4	3.1	2.11	0.05	2.1
9M	0.379	0.710	1.9	3.1	1.89	0.36	2.5
5M	0.467	1.175	2.5	2.3	4.06	1.72	2.5
13F	0.374	0.740	2.0	2.1	2.66	0.79	2.5
8F	0.413	0.685	1.7	2.8	2.83	0.67	1.9
x̄		0.781	1.9	2.7	2.71	0.72	2.3
s		0.226	0.4	0.5	0.85	0.63	0.3
		4 g γ-GC
12M	0.317	0.992	3.1	3.7	4.56	2.26	3.2
5M	0.473	1.140	2.4	2.2	3.42	1.52	2.5
13F	0.356	0.822	2.3	2.5	3.02	1.24	2.5
8F	0.347	1.350	3.9	3.5	3.98	2.20	2.6
x̄	0.397	1.076	2.9	3.0	3.75	1.81	2.6
s	0.055	0.224	0.7	0.7	0.67	0.50	0.5

C_max – Maximum [GSH]. [GSH] units - nmol GSH]/10⁶ lymphocytes. C₀ – Basal [GSH] before GSH administration. T_max – Time (h) to reach C_max. AUC – Area under the curve (nmol GSH h/10⁶ lymphocytes) based on C_t values. ΔAUC – based on (C_{t –} C₀).