Fig. 3.

Manhattan plots representing all phenotype associations for the five single nucleotide polymorphisms (SNPs) with the lowest P-values for atazanavir pharmacokinetic, HIV-1 RNA, and CD4 T-cell phenotypes. We analyzed SNPs that were annotated previously for any drug in the PharmGKB or previously associated with any trait in the GWAS Catalog, and that were also represented in the imputed, post-QC genome-wide data. Each marker represents, for each phenotype, the –log₁₀ P-value for association with the indicated SNP. Color-coded phenotype categories are indicated at the bottom left of the figure. Note that the scale of the Y-axis differs between plots.