Table 1.
Demographical, biochemical, histological, and imaging characteristics of study cohort
| Patients (n=104) | |
|---|---|
| Demographic | |
| Age at biopsy, mean (s.d.) | 50.8 (14.6) |
| Male, n (%) | 45 (43.3) |
| Female, n (%) | 59 (56.7) |
| Height (m), mean (s.d.) | 1.7 (0.1) |
| Weight (kg), mean (s.d.) | 86.1 (17.9) |
| BMI (kg/m2), mean (s.d.) | 30.4 (5.2) |
| Race | |
| White, n (%) | 48 (47.1) |
| African American, n (%) | 0 (0) |
| Asian, n (%) | 21 (20.5) |
| Hispanic, n (%) | 32 (31.4) |
| Other, n (%) | 1 (1.0) |
| Diabetes, n (%) | 29 (27.9) |
| Biochemical profile | |
| AST (U/l), median (iqr) | 31.0 (15.0) |
| ALT (U/l), median (iqr) | 42.0 (34.0) |
| AST/ALT ratio, median (iqr) | 0.8 (0.4) |
| Alkaline Phosphatase (U/l), median (iqr) | 71.0 (30.5) |
| GGT (U/l), median (iqr) | 35.0 (37.0) |
| Total bilirubin (mg/dl), median (iqr) | 0.4 (0.3) |
| Direct bilirubin (mg/dl), median (iqr) | 0.2 (0.1) |
| Albumin (g/dl), median (iqr) | 4.5 (0.5) |
| Glucose (mg/dl), median (iqr) | 98.0 (31.5) |
| Hgb A1C (%), median (iqr) | 5.8 (0.8) |
| Insulin (u), median (iqr) | 21.5 (20.0) |
| Triglycerides (mg/dl), median (iqr) | 133.0 (92.0) |
| Total cholesterol (mg/dl), median (iqr) | 180.0 (56.0) |
| HDL (mg/dl), median (iqr) | 47.0 (19.0) |
| LDL (mg/dl), median (iqr) | 100.0 (52.0) |
| Platelet count (109/L), median (iqr) | 223000 (77000) |
| Prothombin time, median (iqr) | 10.8 (1.0) |
| INR, median (iqr) | 1.0 (0.1) |
| Histology | |
| Fibrosis | |
| 0 | 47 (45.6) |
| 1 | 24 (23.3) |
| 2 | 11 (10.7) |
| 3 | 13 (12.6) |
| 4 | 8 (7.8) |
| Steatosis | |
| 0 | 9 (8.7) |
| 1 | 49 (47.6) |
| 2 | 29 (28.2) |
| 3 | 16 (15.5) |
| Lobular inflammation | |
| 0 | 4 (3.9) |
| 1 | 53 (52.0) |
| 2 | 41 (40.2) |
| 3 | 4 (3.9) |
| Ballooning | |
| 0 | 43 (43.4) |
| 1 | 44 (44.4) |
| 2 | 12 (12.2) |
| NASH | |
| No NAFLD, n (%) | 4 (4.0) |
| NAFLD, not NASH, n (%) | 20 (20.0) |
| Borderline NASH, n (%) | 13 (13.0) |
| Definite NASH, n (%) | 63 (63.0) |
| NAS mean (SD) | 3.8 (1.4) |
| Imaging | |
| TE (kPa), median (IQR) | 6.1 (4.6) |
| CAP, median (IQR) | 299 (80.0) |
| MRE(kPa), median (IQR) | 2.7 (1.0) |
| MRI-PDFF (%), median (IQR) | 11.5 (10.4) |
| Use of M probe, n (%) | 51 (49.0) |
| Use of XL probe, n (%) | 53 (51.0) |
| Technical Failures of Fibroscan, n (%) | 7 (6.7) |
Abbreviations: ALT, Alanine aminotransferase; AST, Aspartate aminotransferase; BMI, Body mass index; GGT, Gamma-glutamyl transpeptidase; HDL, high-density lipoprotein; Hgb, Hemoglobin; INR, international normalized ratio; kPa, kilopascal; NAFLD, LDL, low-density lipoprotein; Nonalcoholic fatty liver disease; NAS, NAFLD activity score; NASH, Nonalcoholic steatohepatitis; SD, Standard deviation