FIGURE 1.

The canonical fungal ergosterol biosynthetic pathway. Biosynthesis of ergosterol from Acetyl-coA depicting intermediate steps and enzymes catalyzing the intermediate reactions. Known regulators of Erg genes are shown on right side, whereas anti-fungal agents targeting various pathway steps are shown on the left of the pathway. ^∗Signifies the pathway differences in Aspergillus fumigatus and Saccharomyces cerevisiae. In S. cerevisiae, Cyp51 converts lanosterol into C4 methylated sterols which are demethylated by Erg24 and Erg25 into zymosterol. Erg6 then converts zymosterol into fecosterol.