Table 4.
Predicteda miRNA150 target genes.
| Target gene | Full name | Potential binding sitesb | ΔΔGc | Validated |
|---|---|---|---|---|
| MAPK8 | Mitogen-activated protein kinase 8 | 1 | −12.38 | No |
| FZD4 | Frizzled family receptor 4 | 1 | −8.94 | Yes |
| DAAM2 | Disheveled-associated activator of morphogenesis 2 | 1 | −9.87 | No |
| PRKX | Protein kinase, X-linked | 2 | −12.68, −9.81 | No |
| FRAT2 | Frequently rearranged in advanced T-cell lymphomas 2 | 2 | −19.27, −8.04 | No |
| DVL3 | Disheveled, dsh homolog 3 | 1 | −8.09 | No |
| LRP5 | Low-density lipoprotein receptor-related protein 5 | 1 | −16.42 | No |
| APC | Adenomatous polyposis coli | 1 | −11.51 | No |
| PRKACA | Protein kinase, cAMP-dependent, catalytic α | 1 | −12.16 | No |
| NFAT5 | Nuclear factor of activated T-cell 5 | 2 | −12.43, −8.84 | No |
| FZD7 | Frizzled family receptor 7 | 1 | −13.9 | No |
| CREBBP | CREB binding protein | 1 | −10.29 | No |
| CCND1 | Cyclin D1 | 1 | −13.9 | No |
| PRICKLE2 | Prickle homolog 2 | 3 | −16.17, −15.12, −11.45 | No |
| NFATC4 | Nuclear factor activated of T-cells, cytoplasmic, calcineurin-dependent 4 | 1 | −8.07 | No |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | 2 | −11.35, −8.53 | No |
| CCND2 | Cyclin D2 | 1 | −9.2 | No |
| CAMK2G | Calcium/calmodulin-dependent protein kinase II γ | 1 | −10.98, −9.19 | No |
| DVL2 | Disheveled, dsh homolog 2 | 1 | −11.46 | No |
aTarget prediction was performed using the PITA (https://genie.weizmann.ac.il) and TargetScan (http://www.targetscan.org) platforms.
bOnly the potential interaction sites with a ΔΔG ≤ 8 are were considered.
cΔΔG values were calculated using PITA.