Figure 3.

Reduced proinflammatory cytokine expression in the brain of Cyld^−/− mice. Quantitative reverse transcription polymerase chain reaction analysis of intracerebral cytokines interferon-γ, perforin, granzyme B, tumor necrosis factor, interleukin-6, lymphotoxin-α, and chemokines CXCL-9 and CXCL-10 mRNA expression in WT and Cyld^−/− mice. Data show the increase of the respective mRNA expression of Plasmodium berghei ANKA-infected over uninfected mice of the same mouse strain. Data represent the mean (±SD) of six mice, *p < 0.05 (two-tailed Student’s t-test). Data from two independent experiments are shown.