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. 2017 Feb 1;8:27. doi: 10.3389/fimmu.2017.00027

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Copyright © 2017 Schmid, Stenzel, Koschel, Raptaki, Wang, Naumann, Matuschewski, Schlüter and Nishanth.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diminished CD8⁺ T cell response in the brain of Cyld^−/− mice. (A,B) Absolute (A) and representative relative (B) numbers of CD3⁺ CD8⁺ T cells of uninfected (day 0) and Plasmodium berghei ANKA (PbA)-blood stage-infected mice (day 7) were determined by flow cytometry in the brains of WT and Cyld^−/− mice (n = 6 each). (C) Absolute numbers of H2-Db SQLLNAKYL pentamer⁺ CD44⁺ CD8⁺ T cells. (D) Absolute numbers of interferon (IFN)-γ, tumor necrosis factor, and granzyme B-producing CD8⁺ T cells of uninfected (day 0) and PbA-infected mice (day 7) after ex vivo restimulation with GAP-50 peptide. (E) Representative relative numbers of IFN-γ-producing CD8⁺ T cells from (D), *p < 0.05 (two-tailed Student’s t-test). (A–E) Data from one of three independent experiments are shown.