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. 2017 Feb 1;8:27. doi: 10.3389/fimmu.2017.00027

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Copyright © 2017 Schmid, Stenzel, Koschel, Raptaki, Wang, Naumann, Matuschewski, Schlüter and Nishanth.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CD4⁺ T cell responses increase in the blood and decrease in the brain of Cyld^−/− mice. (A,B) Total numbers of CD3⁺ CD4⁺ T cells in blood (A) and brain (B) of uninfected (day 0) and Plasmodium berghei ANKA (PbA)-infected (day 7) WT and Cyld^−/− mice were determined by flow cytometry (n = 6 each), *p < 0.05 (two-tailed Student’s t-test) (C–F) Absolute (C) and representative relative (E) numbers of interferon (IFN)-γ-producing CD4⁺ T cells in blood and absolute (D) and representative relative (F) numbers of IFN-γ-producing CD4⁺ T cells in the brain from uninfected (day 0) and PbA-infected mice (day 7) after ex vivo restimulation with anti-CD3/CD28 (n = 6 each), *p < 0.05 (two-tailed Student’s t-test). Data from one of three independent experiments are shown.