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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Trends Genet. 2016 Dec 21;33(2):129–142. doi: 10.1016/j.tig.2016.11.007

Figure 3. A Brief Overview of Cap-Dependent Translation and IRES-mediated, Cap-Independent Translation.

Figure 3

Mammalian cap-dependent translation functions through the use of all the canonical initiation factors as well as circularization of the mRNA through the interaction of PABP and eIF4G. Key initiation factors are pictured here. Cap-independent IRES-mediated translation is thought to require a subset of ITAFs, an unknown number canonical initiation factors, and may require circularization.