Table 4.

Multivariate Cox regression analysis for overall mortality of 496 patients undergoing curative abdominal resections for stage I–III colorectal cancer

		Preoperative anaemia	Transfusion (± 1 day)	Preoperative anaemia and transfusion
	Events/person-years	Hazard ratio (95% CI)	Hazard ratio (95% CI)	Hazard ratio (95% CI)
Anaemia
Yes	95/1058.5	2.1 (1.4–3.2)**		2.3 (1.5–3.6)***
No	36/1129.4	1.00 (ref)		1.00 (ref)
Transfusion
Red blood cell	67/848		1.04 (0.7–1.6) ns	0.8 (0.5–1.2) ns
No transfusion	64/1339.9		1.00 (ref)	1.00 (ref)
Sex
Female	53/1066.9	0.6 (0.4–0.9)*	0.6 (0.4–0.9)**	0.6 (0.4–0.9)*
Male	78/1121	1.00 (ref)		1.00 (ref)
ASA grade
1	11/382.3	1.00 (ref)	1.00 (ref)	1.00 (ref)
2	49/1147	1.1 (0.5–2.3) ns	1.2 (0.6–2.4) ns	1.1 (0.5–2.4) ns
3	57/576.8	1.9 (0.9–4.1) ns	2.2 (1–4.7)*	2 (0.96–4.4) ns
4	14/81.7	3.8 (1.6–9.2)**	4 (1.6–10)**	4.3 (1.7–10.6)**
pT
1	5/270.2	1.00 (ref)	1.00 (ref)	1.00 (ref)
2	23/411.5	2.3 (0.8–6) ns	2.3 (0.9–6.2) ns	2.2 (0.8–6) ns
3	68/1163.5	1.4 (0.6–3.6) ns	1.8 (0.7–4.5) ns	1.4 (0.6–3.7) ns
4	35/342.7	1.8 (0.7–5) ns	2.5 (0.9–6.7) ns	1.9 (0.7–5.1) ns
pN
0	86/1565.1	1.00 (ref)	1.00 (ref)	1.00 (ref)
1	20/463.8	0.8 (0.5–1.4) ns	0.9 (0.5–1.4) ns	0.8 (0.5–1.4) ns
2	25/159	3.6 (2.2–5.8)***	3.8 (2.3–6.1) ***	3.6 (2.2–5.9)***
Type of surgery
Colon resection	84/1187.7	1.00 (ref)	1.00 (ref)	1.00 (ref)
Low anterior resection + Hartmann	24/642	0.6 (0.3–1.2) ns	0.5 (0.2–1.1) ns	0.5 (0.3–1.1) ns
Abdomino-perineal resection	23/358.2	0.8 (0.3–1.8) ns	0.7 (0.3–1.8) ns	0.7 (0.3–1.7) ns
Neo-adjuvant treatment
Yes	40/820.8	1.4 (0.7–3) ns	1.4 (0.7–3) ns	1.5 (0.7–3.1) ns
No	91/1367.1	1.00 (ref)	1.00 (ref)	1.00 (ref)

Analyses adjusted for age and blood loss as restricted cubic splines, 3 df

*p < 0.05; **p < 0.01; ***p < 0.001