Table 3.
Immune mediator levels in aqueous humor of patients with malignant and benign pigmented intraocular tumors
| Malignant (n = 13) | Benign (n = 13) | p value | |
|---|---|---|---|
| Angiogenin (pg/ml) | 21962.4 (4978.7−84479.6) | 7071.6 (0−11589.6) | 0.0257 |
| bFGF (pg/ml) | 21.0 (0−259.7) | 6.1 (0−27.7) | 0.6629 |
| CD40 ligand (pg/ml) | 0 | 0 | |
| Eotaxin (pg/ml) | 0 | 0 | |
| Fas ligand (pg/ml) | 75.9 (0−807.7) | 157.2 (0−1565.4) | 0.3833 |
| Fractalkine (pg/ml) | 3.2 (0−15.9) | 23.8 (0−298.8) | 0.6081 |
| G-CSF (pg/ml) | 1.1 (0−7.8) | 14.6 (0−105.3) | 0.3833 |
| GM-CSF (pg/ml) | 0 | 0 | |
| Granzyme A (pg/ml) | 0.3 (0−1.8) | 7.7 (0−74.5) | 0.5554 |
| Granzyme B (pg/ml) | 0.3 (0−3.7) | 13.6 (0−167.6) | 0.4887 |
| IFN-γ (pg/ml) | 0.4 (0−5.4) | 0.5 (0−6.3) | 0.9795 |
| IL-1α (pg/ml) | 0 | 0 | |
| IL-1β (pg/ml) | 0 | 0 | |
| IL-2 (pg/ml) | 0 | 0 | |
| IL-3 (pg/ml) | 0 | 0 | |
| IL-4 (pg/ml) | 0 | 0 | |
| IL-5 (pg/ml) | 2.7 (0−19.2) | 0 | 0.505 |
| IL-6 (pg/ml) | 1185.8 (2.1−13635.8) | 196.8 (0−683.4) | 0.7005 |
| IL-8 (pg/ml) | 525.6 (16.0−3428.7) | 33.3 (0−128.6) | 0.0052 |
| IL-9 (pg/ml) | 0 | 0 | |
| IL-10 (pg/ml) | 2.9 (0−27.7) | 0 | 0.3173 |
| IL-11 (pg/ml) | 0.8 (0−10.3) | 15.0 (0−194.8) | 0.9795 |
| IL-12p70 (pg/ml) | 0 | 0 | |
| IL-17A (pg/ml) | 0.4 (0−2.6) | 5.5 (0−68.7) | 0.9183 |
| IL-21 (pg/ml) | 3.0 (0−38.6) | 41.3 (0−500.5) | 0.7389 |
| IP-10 (pg/ml) | 1133.9 (60.8−7540.0) | 310.0 (0−1550.4) | 0.0687 |
| ITAC (pg/ml) | 0 | 0 | |
| LT-α (pg/ml) | 0 | 0 | |
| MCP-1 (pg/ml) | 2416.7 (600.1−7723.0) | 533.7 (117.3−1712.3) | 0.0002 |
| Mig (pg/ml) | 1727.8 (0−13496.1) | 141.9 (11.8−553.6) | 0.209 |
| MIP-1α (pg/ml) | 0.2 (0−2.5) | 0.9 (0−10.4) | 0.7389 |
| MIP-1β (pg/ml) | 21.9 (0−125.4) | 22.3 (0−64.8) | 0.7005 |
| RANTES (pg/ml) | 131.5 (0−1710.9) | 15.9 (0−207.3) | 0.2592 |
| TNF-α (pg/ml) | 0 | 0 | |
| VEGF (pg/ml) | 275.0 (0−1993.7) | 55.4 (0−146.0) | 0.1824 |
Immune mediator levels are expressed as mean (range).
bFGF = basic fibroblast growth factor; G-CSF = granulocyte colony-stimulating factor;
GM-CSF = granulocyte macrophage colony-stimulating factor; IFN = interferon; IL = interleukin;
IP-10 = interferon gamma-induced protein 10 kDa; ITAC = interferon-inducible T-cell alphachemoattractant;
LT-α = lymphotoxin-α; MCP = monocyte chemoattractant protein;
Mig = monokine induced by interferon γ; MIP = macrophage inflammatory protein;
RANTES = regulated upon activation normal T expressed and presumably secreted;
TNF = tumor necrosis factor; VEGF = vascular endothelial growth factor