Table 1.
Clinical characteristics of participants in the low risk reference sub-group and the larger ARIC sample with CV risk factors but no prevalent HF.
| Low Risk Reference Subgroup (n=401) |
HF Risk Factors but No Prevalent HF (n=5,400) |
P value | |
|---|---|---|---|
| Age (years) | 74.7 ± 4.6 | 76.0 ± 5.1 | <0.001 |
| Male | 136 (34 %) | 2277 (42 %) | 0.001 |
| Black | 28 (7 %) | 1216 (23 %) | <0.001 |
| Field Center | <0.001 | ||
| Forsyth County, NC | 116 (28.9%) | 1240 (23.0%) | |
| Jackson, MS | 25 (6.2%) | 1104 (20.4%) | |
| Minneapolis, MN | 161 (40.1%) | 1588 (29.4%) | |
| Washington County, MD | 99 (24.7%) | 1468 (27.2%) | |
| Hypertension | 0 | 4795 (89 %) | |
| Diabetes | 0 | 2120 (39 %) | - |
| Obesity | 0 | 1948 (36 %) | - |
| Chronic Kidney Disease | 0 | 1553 (29 %) | - |
| Atrial Fibrillation | 0 | 414 (8 %) | - |
| Current Smoking | 0 | 336 (6 %) | - |
| Any Prior Smoking | 217 (54 %) | 3319 (61 %) | 0.004 |
| BMI (kg/m2) | 24.9 ± 2.7 | 28.8 ± 5.6 | <0.001 |
| Systolic blood pressure (mmHg) | 121 ± 11 | 131 ± 18 | <0.001 |
| Diastolic blood pressure (mmHg) | 64 ± 8 | 67 ± 11 | <0.001 |
| Heart rate (bpm) | 60 ± 8 | 63 ± 11 | <0.001 |
| LV Ejection Fraction (%) | 66.3 ± 4.8 | 65.4 ± 6.4 | 0.007 |
| NT-proBNP (ng/ml) | 90 [54, 153] | 131 [68, 256] | <0.001 |
| hs-Troponin T (ng/ml) | 7 [5, 10] | 11 [7, 16] | <0.001 |
| hs-C reactive protein | 1.3 [0.7, 2.5] | 2.0 [1.0, 4.2] | <0.001 |
| eGFR | 77.5 ± 9.9 | 69.6 ± 17.2 | <0.001 |