Table 4.

Risk of death or HF hospitalization associated with abnormal septal and lateral TDI e’ based on ARIC-based versus guideline cutpoints, and results of analysis to identify optimal predictive cutpoints, in persons ≥65 years old in the general population (ARIC), with atrial fibrillation and cardiovascular risk factors but no HF (ENGAGE-TIMI 48), and with HFpEF (TOPCAT).

	ARIC	ENGAGE AF-TIMI 48 Echo Sub-study	TOPCAT Echo Sub-study
Septal TDI e’ (cm/sec)	<5.0	<4.0	<4.0
N	5,784	588	348
Events	177	93	120
Risk using ARIC limits   [<4.5 (F), <4.6 (M)]	1.66 (1.20–2.29), p=0.002	1.74 (1.06–2.86), p=0.028	2.03 (1.38–2.99), p<0.001
Risk using Guideline limits   [<7]	1.11 (0.74–1.68), p=0.61	1.05 (0.69–1.61), p=0.82	1.42 (0.93–2.18), p=0.10
‘Optimal cutpoint’ analysis	<5.0	<4.0	<4.0
Lateral TDI e’ (cm/sec)
N	5,774	590	344
Events	177	94	114
Risk using ARIC limits   [<5.1 (F, <5.4 (M)]	1.64 (1.18–2.28), p=0.004	1.36 (0.75–2.45), p=0.31	1.16 (0.71–1.88), p=0.56
Risk using Guideline limits   [<10]	0.80 (0.49–1.30), p=0.61	1.01 (0.65–1.57), p=0.95	0.80 (0.52–1.23), p=0.30
‘Optimal cutpoint’ analysis	<5.0	<5.0	<4.0

Outcomes: ARIC – incident HF or all cause mortality; ENGAGE-TIMI 48 – incident HF or all cause mortality; TOPCAT – HF hospitalization or all cause mortality. Risk presented as HR (95% CI) adjusted for age, sex, and race in ARIC and TOPCAT, and for age and sex in ENGAGE AF-TIMI 48.