Table I.
Phenotypes of Hippo Pathway Mutants in the Liver
| Mutation | Genotype | Phenotype | References |
|---|---|---|---|
| YAP overexpression | ApoE-rtTA; TRE Yap | hepatomegaly, HCC | 20 |
| LAP1-tTA;TetO-Yap(S127A) | hepatomegaly, HCC | 19 | |
| Ck19-CreERT2;TetO-Yap(S127A) | ductal hyperplasia | 30 | |
| AAV-Cre; TetO-Yap(S127A) | dedifferentiation, hepatomegaly, HCC | 30 | |
| Yap(S112A)/Yap(S112A) | no change at baseline, hypertrophy after injury | 24 | |
| YAP knockout | AAV-TBG-Cre; Yap fl/fl | hepatocyte sensitivity to stress | 30 |
| Alb-Cre; Yap fl/fl | biliary and hepatocyte hypoplasia | 42 | |
| MOB1A and MOB1B | Mob1a Δ/Δ 1b tr/+ | HCC development | 26, 27 |
| Knockout of MST1 and MST2 | Ad-Cre; Mst1−/−; Mst fl/fl | HCC development | 21 |
| Alb-Cre; Mst1−/− Mst fl/- | 22 | ||
| Alb-Cre; Mst1−/− Mst fl/fl | 23 | ||
| Knockout of NF2 | Alb-Cre; Nf2 fl/fl | biliary ductular reaction, HCC | 42 |
| Ad-Cre; Nf2 fl/fl | 43 | ||
| Knockout of SAV | Alb-Cre; Sav1 fl/fl | Hepatic progenitor expansion, HCC, CC | 25 |
| Knockout of NF2 and SAV | Alb-Cre; NF2 fl/fl Sav1 fl/fl | Biliary cell hyperplasia | 44 |
| Knockout of LATS1 and LATS2 | Ad-Cre; Lats1−/−; Lats 2 fl/fl | Hepatomegaly, biliary cell expansion | 24 |
| Knockout of α-catenin | ΛNΠ α-catenin siRNA | Hepatomegaly, disorganized sinusoids, cholestasis, | 51 |