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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Exp Neurol. 2016 Dec 28;289:85–95. doi: 10.1016/j.expneurol.2016.12.012

Figure 1.

Figure 1

Microscopic evaluation of longitudinal sections through the optic nerves from sham and 4 day post-mTBI mice (A & C) and confocal microscopic evaluation of the downstream axon terminals in dLGN through VGLUT2 immunohistochemistry (B & D). Sham-injured mouse optic nerve revealed normal histology with numerous thinly myelinated axons identifiable (arrowheads). The downstream axon terminals form scattered large clusters visualized in magenta with surrounding cell nuclei visualized in blue (B). By comparision, 4 days after injury, the optic nerve reveals axonal swellings (arrows) with pathologic accumulation of intracellular components and vescicles adjacent to normal appearing thinly myelinated axons (C). Downstream of the injured optic nerve was diffuse reduction in the large clusters of axon terminals visualized in magenta with surrounding nuclei in blue (D). Scale bars = 10 µm.