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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Epidemiology. 2017 Mar;28(2):266–274. doi: 10.1097/EDE.0000000000000609

Table 4.

Randomly interventional analogue of total effect, of natural direct effect, and of natural indirect effect for the effect of smoking 20 cigarettes per day for 10 years (compared with no smoking) on SBP, mediated by BMI change over time.

Estimate 95% CI
E[Y0G0] 135.691 134.93, 137.11
E[Y1G0] 137.211 135.76, 138.80
E[Y0G1] 135.336 134.57, 136.69
E[Y1G1] 136.874 135.64, 138.37
rTE 1.18 −0.68, 2.69
rNDE 1.52 −0.25, 2.90
rNIE −0.34 −0.52, −0.13

rTE: randomly interventional analogue of total effect; rNDE: randomly interventional analogue of natural direct effect; rNIE: randomly interventional analogue of natural indirect effect; CI: confident interval; E[Y0G0], E[Y1G0], E[Y0G1], and E[Y1G1]

represent “no smoking with BMI distributed as the BMI under no smoking”,

“smoking 20 cigarettes per day with BMI distributed as the BMI under no smoking”,

“no smoking with BMI distributed as the BMI under smoking 20 cigarettes per day”,

and “smoking 20 cigarettes per day with BMI distributed as the BMI under smoking 20 cigarettes per day”, respectively.