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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Differentiation. 2016 Dec 3;93:58–65. doi: 10.1016/j.diff.2016.11.003

Fig.1. Satellite cells from jaw muscles are derived from the secondary heart field and express cardiac transcription factors in response to BMP4.

Fig.1

A. Isl1-Cre;mT/mG mouse, frontal section through the head of E13.5 embryo showing that jaw muscles are derived from Isl1-positive precursors. High power views are shown on the right. Myofibers, immunostained for MF20, and satellite cells, immunostained for PAX7, are both derived from Isl1-positive precursors. White boxes on low magnification image indicate the location of the high magnification images on the right. The masseter (ma) consists of both deep and superficial masses; (ad) anterior digastric; (my) mylohyoid; (t) tongue; (tm) temporalis; (eom) extraocular muscles; (br) brain. Scale bars: 100μm. B. Schematic of representative muscles of adult mice used to prepare satellite cells, and typical sequential FACS plot. C. Absence of difference between jaw and trunk-derived satellite cells in myogenic transcription factor gene expression in the presence of BMP4 (day 3). D. Upregulation of cardiogenic transcription factor genes in jaw but not trunk satellite cells in the presence of BMP4 (day 3).